abstract：:The ability of cells to utilize cholesterol derived from lipoprotein is important in plasma membrane biosynthesis, steroidogenesis and the regulation of sterol synthesis. While the endocytosis of lipoprotein-derived cholesterol has been well characterized, the subsequent events that mediate its post-lysosomal intracel...

journal_title：Trends in cell biology

authors： Evans RM

更新日期：1994-05-01 00:00:00

abstract：:The mechanisms responsible for cytokinesis and its coordination with other events of the cell cycle are poorly understood. Genetic studies of cytokinesis in fission yeast are one useful approach to this problem. A number of conditional mutants of fission yeast that show defects in the formation of the septum of cytoki...

journal_title：Trends in cell biology

authors： Fankhauser C,Simanis V

更新日期：1994-03-01 00:00:00

abstract：:Plant seeds store nitrogen by accumulating storage proteins in protein bodies within various compartments of the endomembrane system. The prolamin storage proteins of some cereal species are normally retained and assembled into protein bodies within the ER. Yet, these proteins lack a C-terminal KDEL/HDEL signal, sugge...

journal_title：Trends in cell biology

authors： Galili G,Altschuler Y,Levanony H

更新日期：1993-12-01 00:00:00

abstract：:Ciliary movement is powered by axonemal dynein. This article considers how a signal transduction cascade initiated at the cell membrane may activate outer dynein arms to change the velocity of microtubule sliding and the swimming speed of ciliated cells. For Paramecium, a critical event in the cascade is the cAMP-depe...

journal_title：Trends in cell biology

authors： Satir P,Barkalow K,Hamasaki T

更新日期：1993-11-01 00:00:00

abstract：:Nuclear proteins are transported from the cytoplasm into the nucleus via nuclear envelope pore complexes (NPCs). At the molecular level, the mechanisms responsible for this transport remain obscure. However, it is known that, for many proteins, the process requires ATP and proceeds against formidable nucleocytoplasmic...

journal_title：Trends in cell biology

authors： Paine PL

更新日期：1993-10-01 00:00:00

abstract：:In vitro cell biology has become an effective way to identify molecules responsible for membrane traffic. We have used this approach to study the assembly and budding of coated pits. So far our system has allowed us to identify a high-affinity binding site for the AP2 subunit on the inside surface of plasma membranes,...

journal_title：Trends in cell biology

authors： Anderson RG

更新日期：1993-06-01 00:00:00

abstract：:How do the many different components of an organelle assemble into a functional structure at an appropriate place and time? Flagellar regeneration by the biflagellate green alga Chlamydomonas is one experimental system in which genetics, biochemistry and ultrastructural analysis are being combined to investigate the a...

journal_title：Trends in cell biology

authors： Johnson KA,Rosenbaum JL

更新日期：1993-05-01 00:00:00

abstract：:When starved, the fission yeast Schizosaccharomyces pombe responds by producing mating factors or pheromones that signal to cells of the opposite sex to initiate mating. Like its distant relative Saccharomyces cerevisiae, cells of the two mating types of S. pombe each produce a distinct pheromone that binds to recepto...

journal_title：Trends in cell biology

authors： Nielsen O

更新日期：1993-02-01 00:00:00

abstract：:Vesicular transport of proteins and lipids between distinct subcellular compartments is directly responsible for generating and maintaining the structure of the organelles of the secretory and endocytic pathways in eukaryotic cells. Rapid advances in a variety of experimental systems have resulted in the identificatio...

journal_title：Trends in cell biology

authors： Sztul ES,Melançon P,Howell KE

更新日期：1992-12-01 00:00:00

abstract：:Formation of secretion granules in regulated secretory cells involves packaging a subject of proteins undergoing intracellular transport into specific vesicular carriers that function in stimulus-dependent exocytosis. Recent findings suggest that immature granules are a site of passive sorting, involving condensation ...

journal_title：Trends in cell biology

authors： Arvan P,Castle D

更新日期：1992-11-01 00:00:00

abstract：:Proteins of the cyclophilin family display two intriguing properties. On the one hand, they are the intracellular receptors for the immunosuppressive drug cyclosporin A (CsA); on the other hand, they function in vitro as enzymes that catalyse slow steps in protein folding. A dissection of the role of CsA in mediating ...

journal_title：Trends in cell biology

authors： Stamnes MA,Rutherford SL,Zuker CS

更新日期：1992-09-01 00:00:00

abstract：:Sphingomyelin used to be considered only as a structural molecule of the outer leaflet of the plasma membrane of mammalian cells. However, in the last five years it has become clear that sphingomyelin is rapidly degraded and resynthesized in a pathway that could function in signal transduction. Indeed, it is now known...

journal_title：Trends in cell biology

authors： Kolesnick R

更新日期：1992-08-01 00:00:00

abstract：:At least three genes that play crucial roles in dorsal-ventral patterning of the Drosophila embryo appear to encode extracellular proteases. These proteases are involved in the generation of localized extracellular ligands for membrane receptors. Because the sequences of these gene products closely resemble those of m...

journal_title：Trends in cell biology

authors： Hecht PM,Anderson KV

更新日期：1992-07-01 00:00:00

abstract：:The contribution of extracellular matrix (ECM) components to the regulation of cell adhesion, proliferation and differentiation is receiving much attention. Recently, it has become evident that certain cellular responses require the combined action of ECM components and soluble growth factors. This article examines po...

journal_title：Trends in cell biology

authors： Schubert D

更新日期：1992-03-01 00:00:00

abstract：:Microtubules are composed predominantly of two related proteins: alpha- and beta-tubulin. These proteins form the tubulin heterodimer, which is the basic building block of microtubules. Surprisingly, recent molecular genetic studies have revealed the existence of gamma-tubulin, a new member of the tubulin family. Like...

journal_title：Trends in cell biology

authors： Oakley BR

更新日期：1992-01-01 00:00:00

abstract：:Transfer of proteins and lipids between the various membrane-bound subcellular compartments of the eukaryotic cell is mediated by transport vesicles. The development of cell-free assays has allowed rapid progress towards a molecular description of the formation, or budding, of these vesicles. This article reviews and ...

journal_title：Trends in cell biology

authors： Melançon P,Franzusoff A,Howell KE

更新日期：1991-12-01 00:00:00

abstract：:The progress of a cell through its growth cycle is a multifaceted process; so far we have seen only a glimpse of the complex interplay between the macromolecules performing and regulating the different steps involved. In most organisms, control mechanisms ensure that all chromosomal DNA sequences are replicated once, ...

journal_title：Trends in cell biology

authors： Boye E

更新日期：1991-11-01 00:00:00